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CELEXA

Celexa - citalopram - is an antidepressant medication that affects neurotransmitters, the chemical transmitters within the brain. Neurotransmitters manufactured and released by nerves attach to adjacent nerves and alter their activities. Thus, neurotransmitters can be thought of as the communication system of the brain. Many experts believe that an imbalance among neurotransmitters is the cause of depression. Citalopram works by preventing the uptake of one neurotransmitter, serotonin, by nerve cells after it has been released. Such uptake is an important mechanism for removing released neurotransmitters and terminating their actions on adjacent nerves. The reduced uptake caused by citalopram results in more free serotonin in the brain to stimulate nerve cells. Citalopram is in the class of drugs called selective serotonin reuptake inhibitors (SSRIs), a class that also contains fluoxetine (Prozac), paroxetine (Paxil) and sertraline (Zoloft). Citalopram was approved by the FDA in July 1998.

SIDE EFFECTS: The most commonly-noted side effects associated with citalopram are nausea, vomiting, excessive sweating, headache, tremor, and inability to sleep. Overall, between 1 in 6 and 1 in 5 persons experience a side effect. Some patients may experience withdrawal reactions upon stopping some SSRIs such as paroxetine, and such symptoms also may occur with citalopram. Symptoms of withdrawal include dizziness, tingling sensations , tiredness, vivid dreams, irritability or poor mood.

It has been suggested that SSRIs may cause depression to worsen and even lead to suicide in a small number of patients. These potential side effects are difficult to evaluate in depressed patients because depression can progress with or without treatment, and suicide is itself a consequence of depression. Moreover, the evidence supporting these potential side effects is weak.