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COMBIVIR

Combivir, is an antiviral medication. Lamivudine and zidovudine are in a category of HIV medicines called reverse transcriptase inhibitors. They inhibit the reproduction of HIV in the body. Lamivudine and zidovudine are used together to treat the human immunodeficiency virus (HIV), which causes the acquired immunodeficiency syndrome (AIDS). Combivir is not a cure for HIV or AIDS, and you can still transmit the virus to others during therapy with this medication.

The effectiveness of either lamivudine or zidovudine when used alone may decrease as the HIV virus develops resistance to the effects of the individual drugs. By combining lamivudine and zidovudine, it is more difficult for the HIV virus to develop resistance to therapy since it must develop resistance to both drugs. As a result, Combivir is more effective than lamivudine or zidovudine alone. This medication does not kill existing HIV virus, and it is not a cure for HIV. Combivir was approved by the FDA in September, 1997.

SIDE EFFECTS: The most serious side effects are a decrease in blood cells, muscle pain (myopathy) or muscle breakdown (rhabdomyolysis), liver enlargement and metabolic disturbance (lactic acidosis). Other side effects include chills, rash, abdominal pain, nausea and vomiting, weight loss, headache, cough and insomnia. Accumulation or redistribution of fat may also occur.