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CRIXIVAN

Indinavir, is an oral medication that is used for treating infections with the human immunodeficiency virus (HIV). It is in a class of drugs called protease inhibitors which also includes ritonavir (Norvir), nelfinavir (Viracept) and saquinavir (Invirase, Fortovase). Indinavir blocks the activity of protease and results in the formation of defective viruses that are unable to infect the body's cells. As a result, the number of viruses in the body (the viral load) decreases. Nevertheless, This medicament does not prevent the transmission of HIV among individuals, and it does not cure HIV infections or AIDS. Indinavir was approved by the FDA in March, 1995.

SIDE EFFECTS: The most common side effects of indinavir are abdominal pain, weakness, nausea, diarrhea, vomiting, headache, insomnia and abnormal taste sensation. Indinavir may cause hemolytic anemia (break-down of red blood cells), liver failure and kidney stones. Kidney stones may be prevented by adequate fluid intake. Adequate fluid intake can be achieved by consuming at least 48 ounces of fluid daily. Like other protease inhibitors, use of indinavir may be associated with redistribution or accumulation of body fat, increased blood cholesterol and worsening of diabetes.