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FOSAMAX

Alendronate, is used to prevent or treat osteoporosis (bone weakening) in women after menopause and to treat osteoporosis in men. Alendronate may also be used to treat Paget's disease of bone and osteoporosis (bone weakening) caused by glucocorticoid treatment. This medication prevents or slows weakening of bone.

FOSAMAX is indicated for:

• For the treatment of osteoporosis, Alendronate increases bone mass and reduces the incidence of fractures, including those of the hip and spine (vertebral compression fractures). Osteoporosis may be confirmed by the finding of low bone mass or by the presence or history of osteoporotic fracture.

• For the prevention of osteoporosis, Alendronate may be considered in postmenopausal women who are at risk of developing osteoporosis and for whom the desired clinical outcome is to maintain bone mass and to reduce the risk of future fracture. Bone loss is particularly rapid in postmenopausal women younger than age 60. Risk factors often associated with the development of postmenopausal osteoporosis include early menopause; moderately low bone mass; thin body build; Caucasian or Asian race; and family history of osteoporosis.

SIDE EFFECTS: Alendronate is generally well tolerated. Side effects are infrequent and mild. Side effects include stomach pain or upset, constipation, diarrhea, muscle ache, and headache. Alendronate can irritate the esophagus to cause heartburn in patients who lie down flat after swallowing, thereby delaying passage of the medication to the stomach.