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IMDUR

Isosorbide mononitrate - generic Imdur - is a form of nitrate used to reduce the number of angina attacks. In most cases, Imdur will not relieve an attack that has already started because it does not act fast enough to relieve the pain of an angina attack. Nitrates work by relaxing blood vessels and increasing the supply of blood and oxygen to the heart while reducing its work load.

The pain of coronary heart disease (angina) usually occurs when the heart requires more blood and oxygen than its blood vessels supplying the heart can deliver. The demand for oxygen can be reduced and pain prevented in one of two ways. First, by dilating the veins and allowing more blood to "pool." This reduces the amount of blood returning to the heart and hence the heart's work and need for oxygen. Second, by dilating the arteries of the body and reducing the pressure within the arteries. This reduces the pressure that the heart has to pump against and hence the Heart's work and need for oxygen. Isosorbide mononitrate reduces angina by dilating both the veins and the arteries.

Imdur also increases supply of oxygen to the heart by dilating the arteries which supply the heart itself. Isosorbide mononitrate is in the class of drugs called anti-anginal medications. Isosorbide mononitrate is the chief metabolite of isosorbide dinitrate, and most of the activity of isosorbide dinitrate is due to its metabolite, isosorbide mononitrate.

SIDE EFFECTS: Headaches are the most common side effect and usually are dose-related (increase with higher dosages). Headaches may occur in about 1 in 10 (10%) to 1 in 5 (20%) of all persons taking Imdur. Far less frequently, dizziness, nausea, vomiting, and palpitations occur.