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ASACOL

Mesalamine is a derivative of salicylic acid and is thought to be the active component of sulfasalazine (Azulfidine), a combination of a sulfa drug and salicylic acid. Mesalamine works as an antiinflammatory agent in treating ulcerative colitis and Crohn's disease. Its benefit is believed to be due to a topical effect on the inflamed bowel. Following rectal administration of mesalamine (by enema or suppository), only 15% of a dose is absorbed. Following oral administration, 28% of a dose is absorbed. Mesalamine was approved by the FDA in December 1987.

SIDE EFFECTS: Mesalamine is usually well-tolerated. Adverse effects that have been reported in large studies include: headache, abdominal pain, diarrhea, nausea, and dizziness. None of these effects, however, were reported more frequently with mesalamine than with placebo. Infrequently, patients may be intolerant of mesalamine, experiencing cramping, abdominal pain, bloody diarrhea, and sometimes fever or rash. In such cases, the medication is stopped. Mesalamine enemas contain sulfites and should be avoided in persons who are sensitive to sulfites.