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Levothyroxine is a synthetic (man-made) version of the principle thyroid hormone, thyroxine (T4), that is made and released by the thyroid gland. Thyroid hormone increases the metabolic rate of cells of all tissues in the body. In the fetus and newborn, thyroid hormone is important for the growth and development of all tissues including bones and the brain. In adults, thyroid hormone helps to maintain brain function, food metabolism, and body temperature, among other effects.

Generic and branded tablets of levothyroxine may differ in the amount of levothyroxine they contain, the absorption of the levothyroxine into the body, and the distribution of levothyroxine throughout the body. This means that ingestion of one mg of generic levothyroxine may not have the same effect on the body as one mg of another generic or branded levothyroxine. Practically speaking, this means that when changing between levothyroxine manufactured by different pharmaceutical companies, a change in dose may be necessary to maintain the desired effect or to prevent toxicity.

SIDE EFFECTS: Levothyroxine therapy is usually well-tolerated. If symptoms occur, often they are due to toxic levels of thyroid hormone and the symptoms are those of hyperthyroidism. Symptoms may include all or some of the following: chest pain, increased heart rate or pulse rate, excessive sweating, heat intolerance, nervousness, headache, insomnia, diarrhea, vomiting, weight loss, or fever. Women may experience irregular menstrual cycles.