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VYTORIN

Vytorin is a combination of ezetimibe (Zetia) and simvastatin (Zocor) that is used for treating high levels of cholesterol in the blood. It reduces total cholesterol and low density lipoprotein (LDL or “bad”) cholesterol while it increases high density lipoprotein (HDL or “good”) cholesterol. Ezetimibe lowers blood cholesterol by blocking the absorption of cholesterol, including dietary cholesterol, from the intestine. Vytorin does not affect the absorption of triglycerides. Simvastatin belongs to a class of drugs called HMG-CoA reductase inhibitors, commonly called "statins.” Statins reduce cholesterol by blocking an enzyme in the liver (HMG-CoA reductase) that produces cholesterol. Vytorin lower total and LDL cholesterol in the blood as well as triglycerides. It also increase HDL cholesterol.

LDL cholesterol is believed to be an important cause of coronary artery disease. Lowering LDL cholesterol levels slows and may even reverse coronary artery disease. Raising HDL cholesterol levels also may slow coronary artery disease. Vytorin was approved by the FDA in July, 2004.

SIDE EFFECTS: The most common side effects are headache, nausea, vomiting, diarrhea, muscle pain, and abnormal liver tests. The most serious potential side effects are liver damage and muscle inflammation or breakdown. Simvastatin is a statin. Therefore it shares side effects, such as liver and muscle damage, that are associated with statins. Inflammation of the muscles caused by statins can lead to a serious breakdown of muscle cells called rhabdomyolysis. To prevent the development of rhabdomyolysis, patients taking Vytorin should contact their healthcare provider immediately if they develop unexplained muscle pain, weakness, or muscle tenderness.